Comparative induction of benign prostate hyperplasia using testosterone propionate and estradiol benzoate in rabbit model

Authors: Adamu A. Abubakar, Mukaddas M. Ahmad, Ridwanat Folorunsho, Umar S. Ahmad, Ekaete I. Oviawe, Nura Abubakar, Hassan A. Bodinga, Qais Al-Rawahi, Abdullahi Aliyu, et al.

Ger. J. Vet. Res 2024. vol. 4, Iss. 3 pp:176-184
Doi: https://doi.org/10.51585/gjvr.2024.3.0108

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Abstract:

Benign prostatic hyperplasia (BPH) is a common non-cancerous enlargement of the prostate that usually occurs in aging men and some higher mammals. Many studies have been conducted to explore different treatment strategies for managing BPH. However, a suitable animal model for studying BPH is necessary. So far, only a few animal models, such as rat and dog models, have been used for this purpose. This study aimed to compare the assessment of the BPH model induced in rabbits through the administration of exogenous testosterone and estrogen post-bilateral orchidectomy. Fifteen (N=15) indigenous Nigerian rabbits were used for this experiment. The rabbits were orchiectomized and randomly divided into 3 groups: the testosterone, estrogen, and control groups. Seven days after bilateral orchidectomy, BPH was induced using exogenous subcutaneous administration of testosterone (15 mg kg-1), estrogen (0.75 mg kg-1), and normal saline (1 mL) for 4 weeks. After completion of the treatments, prostates were removed. The weight, volume, prostate index, and histologic scoring were determined. There were significant changes (p<0.05) in prostate weight, volume, and index. Testosterone and estrogen-treated groups differed significantly from the control groups. There were no significant differences in all the parameters between the testosterone and the estrogen groups. Histological evaluation revealed hyperplasia of the epithelium of the prostate gland and increased stromal connective tissues with a corresponding increase in the number of glandular units with secretory-filled fluid within the lumens of the glands. The benign prostate hyperplasia rabbit model was developed successfully using exogenous treatment with testosterone propionate. Testosterone appeared to have significant roles in the development of prostate hyperplasia when compared to estrogen.

Keywords:

Data exploration, Animal Science, Effective data analysis, Veterinary data

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