Evaluating the efficacy of poly-herbal powder, dermal spray, and dermal ointment in treating Lumpy Skin Disease (LSD) in Bovines

Authors: Arun H.S. Kumar, Vasanthkumar Sagar, and B.M. Ravindranath

Ger. J. Vet. Res 2026. vol. 6, Iss. 1 pp:16-29
Doi: https://doi.org/10.51585/gjvr.2026.1.0175

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Abstract:

Lumpy Skin Disease (LSD) lacks targeted treatment options and is managed using antibiotics and anti-inflammatory drugs. This study evaluated the efficacy of a novel polyherbal combination therapy in the management of LSD in affected dairy cattle under field conditions. Fifty-two dairy cattle clinically diagnosed with LSD were enrolled in a field trial conducted under veterinary supervision. All animals received LUMPY-NIL herbal powder (containing Azadirachta indica, Eugenia jambolana, Piper longum, Ocimum sanctum, Tinospora cordifolia, Glycyrrhiza glabra, and Cissus quadrangularis) orally at 30 g twice daily, along with topical application of LUMPY-NIL dermal spray (containing Eucalyptus globulus, Ocimum sanctum, Pongamia pinnata, and Cocos nucifera) on closed nodules and LUMPY-NIL ointment (containing Azadirachta indica, Glycyrrhiza glabra, Curcuma longa, Eugenia jambolana, and Tinospora cordifolia) on open wounds. Daily monitoring included clinical signs, lesion progression, systemic symptoms, and milk yield recovery.  Treatment duration varied from 7 to 21 days depending on disease severity. New lesion formation ceased within 2–4 days of treatment initiation. Systemic symptoms such as fever, lethargy, and inappetence resolved within 1–3 days. Open wounds showed progressive healing with no signs of infection, and nodules dried and sloughed off by day 15 in most animals. Milk yield showed partial recovery (20%) on day 7 and returned to baseline by day 15. The reduction in nodule size and number ranged from 81% to 94% on days 10–15. No adverse effects were observed during the treatment period. The polyherbal treatment combination showed potential therapeutic benefits in the management of clinical symptoms under field conditions and may have contributed to improved recovery outcomes in LSD-infected cattle.

Keywords:

Antiviral drugs, Envelope protein, Poxvirus, RNA polymerase inhibitors, Viral entry, Virus replication

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