Efficacy of common anthelmintics against Fasciolosis in naturally infected sheep

Authors: Ahmed M El-Sherif, Ahmed Zaitoun, Sherin R Rouby, Mohamed G Abdelrahman, and Shawky M Aboelhadid

Arch.Life.Sci.Res. 2026. vol. 2, Iss. 1 pp:1-10
Doi: https://doi.org/10.51585/alsr.2026.1.0008

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Abstract:

This study aims to assess the efficacy of commonly used anthelmintics against Fasciola species in naturally infected sheep. In a randomized trial, 30 adult female sheep naturally infected with Fasciola species were divided into 6 groups: 5 treated with understudied drugs and 1 control group. On zero days, each group was treated by one of five anthelmintics: triclabendazole (TCBZ), rafoxanide (Ra), nitroxinil (Ni), oxyclozanide (Oxy), and ivermectin (Iv). Fecal samples from each sheep in all groups were collected on zero days of treatment, then on (seven, 14, and 28 days) post-treatment. Serum samples were collected on day 0 (before treatment) and on day 28 post-treatment for biochemical analysis. The effectiveness of the studied anthelmintics was assessed by the fecal egg count reduction test (EFRT). The results indicated that TCBZ, Ra, Ni, and Oxy achieved 100% efficacy against fasciolosis by the 14th day post-treatment. In contrast, the group treated with ivermectin showed significantly lower efficacy, with 0% EFRT throughout the study (28 days) post-treatment. Regarding the biochemical evaluations, sheep treated with latter anthelmintics showed a moderate increase in the liver enzymes [Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)] compared to the control group. Results indicated that restricted use of TCBZ, Ra, Ni, and Oxy anthelmintics significantly increases their effectiveness and availability in the treatment of fasciolosis. 

Keywords:

Efficacy, Fasciola, Ivermectin, Nitroxinil, Oxyclozanide, Rafoxanide, Triclabendazole

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